Figure 4.

Profiling of epitope specific CD8⁺ T cells in convalescent COVID-19 patients

(A–D) Ancestral and mutant peptide specific CD8⁺ T cells (A and B) and functional subtypes (C and D) in HLA-A2⁺ convalescent COVID-19 patients and healthy donors. HLA-A2 positive PBMCs samples were stained with PE labeled tetramer, PerCP labeled human CD8⁺ antibody, APC labeled human CCR7 antibody, and FITC labeled human CD45RA antibody, and were acquired with flow cytometry. Ancestral and mutant epitope specific CD8⁺ T cells in the same individual were compared in (B) n = 4 per group. The p values were calculated by paired-samples T test. ∗p < 0.05.