Table 3.

The enriched pathways by different doses of MWCNT in various periods of time

1-month exposure
10 µg	Proteasome Degradation, UCH proteinases, Post-translational protein modification, Deubiquitination, Antigen processing: Ubiquitination & Proteasome degradation, DNA Repair, Class I MHC mediated antigen processing & presentation, Metabolism of proteins, Axon guidance
40 µg	Heme Biosynthesis, glycine, serine and threonine metabolic, Metabolism of porphyrins, Lysine degradation, Histone Modifications, PKMTs methylate histone lysines, LncRNA involvement in canonical Wnt signaling and colorectal cancer, Oxidative Stress Induced Senescence, Epigenetic regulation of gene expression, MicroRNAs in cancer
80 µg	The TNF-type receptor Fas induces apoptosis on ligand binding., Dissolution of Fibrin Clot, Prostaglandin Synthesis and Regulation, Ciliary landscape, Genes encoding secreted soluble factors
6-month exposure
1 µg	Bacterial invasion of epithelial cells, RHO GTPases activate KTN1, EPH-Ephrin signaling, Ras Signaling Pathway, Inflammation mediated by chemokine and cytokine signaling pathway, Focal adhesion, Proteoglycans in cancer, Rap1 signaling pathway, Innate Immune System, mTOR signaling pathway, Pathways Regulating Hippo Signaling, Developmental Biology, TGF-beta Signaling Pathway, Apoptosis, Wnt signaling pathway, Nanomaterial-induced Inflammasome Activation, NOD-like receptor signaling pathway, Chemokine signaling pathway, cAMP signaling pathway, Adaptive Immune System, Signaling by VEGF, intrinsic apoptotic, Transcriptional Regulation by TP53, Nephrin/Neph1 signaling in the kidney podocyte
10 µg	The TNF-type receptor Fas induces apoptosis on ligand binding., RHO GTPases activate PAKs, Hemostasis, Prostaglandin Synthesis and Regulation, Nephrotic syndrome, Viral myocarditis, ECM-receptor interaction, Cell surface interactions at the vascular wall, Inflammation mediated by chemokine and cytokine signaling pathway, Fcgamma receptor (FCGR) dependent phagocytosis
40 µg	Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Protein ubiquitination, RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation
80 µg	Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, DNA Damage Bypass, Hematopoietic Stem Cell Differentiation, Protein ubiquitination, Adaptive Immune System, Adipogenesis, Ubiquitin mediated proteolysis
12-month exposure
1 µg	Cell cycle, Regulation of Apoptosis, p53-Dependent G1 DNA Damage Response, Antigen processing and presentation, MAPK6/MAPK4 signaling, Apoptosis, VEGFR2 mediated cell proliferation, MAPK family signaling cascades, Signaling by Wnt, Metabolism of amino acids and derivatives, Signaling by Interleukins
10 µg	Ciliary landscape, Neutrophil degranulation
40 µg	VEGFA-VEGFR2 Signaling Pathway, Leukocyte transendothelial migration, Focal adhesion, Rap1 signaling pathway, PTEN dependent cell cycle arrest and apoptosis, adenosine ribonucleotides de novo biosynthesis, Signaling by Interleukins, MAP2K and MAPK activation, IFN-gamma pathway, Hemostasis, Class I PI3K signaling events, Cytokine Signaling in Immune system, Oncogenic MAPK signaling, Electron Transport Chain, Developmental Biology, Oxidative phosphorylation, TGF-beta Signaling Pathway, ECM-receptor interaction, glomerulonephritis, Genes controlling nephrogenesis
80 µg	Adipogenesis