Table 1.
Baseline characteristics of participants and incidence of outcome diseases by sex-and menopausal stats-specific quartiles of ferritin level in the study cohort (n = 6497) [weighted values]
| All | Ferritin quartiles (µg/L) | |||||
|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | P for trend | ||
| Age | 41 (31–52) | 39 (29–50) | 40 (30–50) | 40 (31–52) | 44 (34–54) | < 0.001 |
| Sex (Pre-W/Post-W/ Men),%) | 32.9/16.6/50.5 | 32.9/16.4/50.7 | 32.2/16.9/50.9 | 33.3/17.2/49.5 | 33.0/15.9/51.1 | 0.887 |
| BMI (Kg/mts2) | 25.7 (23.1–28.6) | 24.9 (22.7–27.8) | 25.3 (22.8–28.1) | 25.8 (23.3–28.5) | 26.6 (24.1–29.9) | < 0.001 |
| Systolic blood pressure (mmHg) | 126 (117–137) | 125 (117–135) | 125 (116.5–135) | 125.5 (116.5–137) | 128.5 (118–140) | < 0.001 |
| Diastolic blood pressure (mmHg) | 70 (63–79) | 69 (62–77) | 69 (62–78) | 70 (64–78) | 73 (65–81) | < 0.001 |
| Smoking status (%) | ||||||
| Never smoker | 39 | 45.4 | 41.1 | 36.1 | 33.0 | < 0.001 |
| Ex-regular or Ex-occasional smoker | 26.3 | 24.4 | 26.3 | 26.1 | 28.4 | |
| Current smoker | 34.7 | 30.2 | 32.6 | 37.8 | 38.6 | |
| Alcohol consumption. Categories of rating units/week Prevalence (%) | < 0.001 | |||||
| Never drank | 4.2 | 5.1 | 5.4 | 3.6 | 2.6 | |
| Ex-drinker | 2.8 | 3.2 | 3.1 | 2.7 | 2.4 | |
| Trivial drinker/Non-zero but under 1 | 10.3 | 12.6 | 10.7 | 9.1 | 8.5 | |
| 1–20 | 63.4 | 64.5 | 62.9 | 65.4 | 60.6 | |
| ≥ 21 | 19.3 | 14.6 | 17.8 | 19.2 | 26.0 | |
| Total cholesterol (mmol/L) | 5.4 (4.7–6.2) | 5.3 (4.6–6.0) | 5.4 (4.6–6.2) | 5.4 (4.8–6.2) | 5.6 (4.9–6.4) | < 0.001 |
| HDL-cholesterol (mmol/L) | 1.4 (1.2–1.7) | 1.4 (1.2–1.7) | 1.4 (1.2–1.7) | 1.4 (1.2–1.7) | 1.4 (1.1–1.7) | 0.007** |
| GGT (IU/L) | 20 (14–32) | 17 (13–25) | 18 (14–27) | 21 (15–33) | 27 (18–45) | < 0.001 |
| Fibrinogen (g/L) | 2.9 (2.4–3.5) | 2.8 (2.3–3.4) | 2.9 (2.4–3.4) | 3.0 (2.5–3.6) | 3.1 (2.6–3.7) | < 0.001 |
| Ferritin (µg/L) | 61 (32–108) | 25 (13–43) | 62 (28–78) | 91 (42–116) | 161 (86–216.8) | < 0.001 |
| Ferritin range by sex/menopausal status* | ||||||
| Premenopausal women (Pre-W) (n = 2239) | 2.0–950 | 2.0–18 | 19–30 | 31–47 | 48–950 | |
| Postmenopausal women (Post-W) (n = 1343) | 3.0–1000 | 3.0–34 | 35–58 | 58–91 | 92–1000 | |
| men (n = 2915) | 3.0–2251 | 3.0–61 | 62–96 | 97–151 | 152–2251 | |
Data for continuous variables are median (interquartile range) *Samples sizes, quartiles and ranges of ferritin levels are based on unweighted values