Fig. 7.

RelB deprivation decreases mouse xenograft tumour lung metastasis. a RM-1 and its generated cell lines were intravenously injected into male C57BL/6 mice. Lung tissues with tumours in the control group and without tumours in the RelB-KO groups were excised and examined. b The expression levels of RelB and PD-L1 in the excised tissues were measured by immunoblots. c Additionally, the expression of RelB and PD-L1 was further quantified by IHC and the relative H-scores were plotted. d The percentages of CD4⁺ and CD8⁺ T cells derived from mouse blood samples were analysed by flow cytometry. *(p < 0.05), **(p < 0.01) show significance between the two groups as indicated. e Depiction of the suggested mechanism underlying RelB-mediated immune evasion of PCa cells