Table 4.

Novel pragmatic aspects of this trial

Clinical situation	Intervention	Outcomes (important to providers and patients)
• Examines gender differences • Allows for extraction of any number of 3rd molars during the surgical visit • Can use any type of anesthesia • Can use post-operative steroids	• Uses medication protocols which can be followed with existing over-the-counter and prescription formularies • Follows decreased FDA-recommended doses for acetaminophen • Allows patients to “get ahead of the pain”	• Follows patients over entire post-operative period (10 days ±5 days) • Primary outcome is pain experience rather than pain relief • Assesses ability to sleep and perform daily activities • Tracks adverse effects • Explores left-over medication which can be diverted • Explores future opioid-seeking behavior