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. Author manuscript; available in PMC: 2022 Feb 17.
Published in final edited form as: Biol Psychiatry. 2021 Sep 9;91(3):313–327. doi: 10.1016/j.biopsych.2021.05.029

Figure 3.

Figure 3.

Conditioning SA on MDD reduces genetic correlation with psychiatric phenotypes but has limited effect on other traits. (A) Comparison of significant genetic correlations with the SA-EUR vs. genetic correlations with SA-EUR∣MDD. Data include 198 significant genetic correlations after Bonferroni correction (p < .05/768 = 6.51 × 10−5) annotated by risk category. (B) Top 30 phenotypes with the most significant genetic correlations with SA-EUR before (gray) and after (red) conditioning on MDD (SA-EUR∣MDD). Full genetic correlation results, including standard errors, are provided in Table S14 in Supplement 2. GP, general practitioner; MDD, major depressive disorder; SA, suicide attempt; SA-EUR, European-only suicide attempt meta-analysis; SA-EUR∣MDD, SA-EUR results after conditioning on major depressive disorder.