Olive oil is high in bioactive compounds and has been associated with lower risk of total and cause-specific mortality in 2 prospective cohorts including 92,383 U.S. men and women followed for up to 28 years. Potential mechanisms of these associations include olive oil being less susceptible to oxidation, having anti-inflammatory and anti-atherogenic properties, improving oxidative stress, endothelial function, lipid profile, insulin sensitivity and blood pressure.