Table 3.
Association of HbA1c with composite criterion and most individual adverse events according to glycemic control subgroups
| Group I (n = 113) |
Group II (n = 40) |
Group III (n = 96) |
Group IV (n = 274) |
P | |
|---|---|---|---|---|---|
| Composite criterion | |||||
| No./Total no. (%) | 75/109 (68.81) | 31/36 (86.11) | 69/92 (75) | 231/270 (85.56) | |
| Unadjusted OR (95% CI) | 1.00 (ref) | 2.81 (1.01-7.86) | 1.36 (0.73-2.53) | 2.69 (1.58-4.56) | .001 |
| Adjusteda OR (95% CI) | 1.00 (ref) | 3.54 (1.18-10.6) | 1.25 (0.63-2.47) | 3.20 (1.76-5.82) | <.001 |
| LGA | |||||
| No./Total no. (%) | 40/106 (37.74) | 20/35 (57.14) | 46/93 (49.46) | 174/268 (64.93) | |
| Unadjusted OR (95% CI) | 1.00 (ref) | 2.20 (1.01-4.78) | 1.62 (0.92-2.84) | 3.05 (1.92-4.87) | <.001 |
| Adjusteda OR (95% CI) | 1.00 (ref) | 2.41 (1.01-5.73) | 1.46 (0.79-2.69) | 3.38 (2.00-5.70) | <.001 |
| Prematurity | |||||
| No./Total no. (%) | 16/110 (14.55) | 7/38 (18.42) | 18/95 (18.95) | 60/271 (22.14) | |
| Unadjusted OR (95% CI) | 1.00 (ref) | 1.33 (0.50-3.52) | 1.37 (0.66-2.87) | 1.67 (0.91-3.05) | .41 |
| Adjusteda OR (95% CI) | 1.00 (ref) | 1.39 (0.50-3.85) | 1.21 (0.56-2.59) | 1.95 (1.03-3.70) | .16 |
| Cesarean section | |||||
| No./Total no. (%) | 44/112 (39.29) | 19/38 (50) | 42/95 (44.21) | 134/274 (48.91) | |
| Unadjusted OR (95% CI) | 1.00 (ref) | 1.55 (0.74-3.24) | 1.23 (0.70-2.13) | 1.48 (0.95-2.31) | .35 |
| Adjusteda OR (95% CI) | 1.00 (ref) | 1.44 (0.67-3.13) | 1.27 (0.71-2.25) | 1.57 (0.97-2.53) | .32 |
Values are expressed as the number/total number (%) and as OR (95% CI).
The composite criterion of complications is defined by the presence of at least 1 of the 5 following complications: pre-eclampsia, LGA, SGA, cesarean, prematurity. The different groups are defined as: group I, HbA1c at first trimester <6.5% and <6% at third trimester, considered as reference group; group II, HbA1c at first trimester ≥6.5% and < 6% third trimester; group III, HbA1c at first trimester <6.5% and >6% at third trimester; group IV, HbA1c at first trimester ≥6.5% and ≥6% at third trimester.
Abbreviations: CI, confidence interval; LGA, large for gestational age; SGA, small for gestational age.
a Adjusted for years of the date of pregnancy
P for global comparisons.