Table 2.
Event rates and multivariate adjusted Cox proportional hazards models for baseline proneurotensin in relation to all-cause mortality (adjusted for age and sex)
| All-cause mortality | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P for trend |
|---|---|---|---|---|---|
| All participants | |||||
| No./events No. | 1158/458 | 1158/442 | 1158/470 | 1158/536 | |
| Pro-NT, median (range), pmol/L | 60.0 (3.00-75.8) | 89.0 (75.9-105) | 123 (105-149) | 190.4 (149-1150) | |
| HR (95% CI) | Ref (1.0) | 0.99 (0.87-1-12) | 1.10 (0.97-1.26) | 1.33 (1.17-1.50) | < .001 |
| Women | |||||
| No./events No. | 600/194 | 661/213 | 711/252 | 691/291 | |
| Pro-NT, median, pmol/L | 60.4 (3.00-75.8) | 89.1 (75.9-104.6) | 122.6 (104.7-148.5) | 192.0 (148.6-1154.5) | |
| HR (95% CI) | Ref (1.0) | 1.03 (0.85-1.25) | 1.11 (0.92-1.34) | 1.42 (1.19-1.70) | < .001 |
| Men | |||||
| No./events No. | 558/264 | 497/229 | 447/218 | 467/245 | |
| Pro-NT, median, pmol/L | 59.9 (0.00-75.8) | 89.6 (75.9-104.5) | 123.3 (104.8-148.3) | 188.4 (148.6-1057.4) | |
| HR (95% CI) | Ref (1.0) | 0.95 (0.80-1.14) | 1.10 (0.92-1.32) | 1.24 (1.04-1.48) | .014 |
Abbreviations: HR, hazard ratio; Pro-NT, proneurotensin; Ref, reference.