Table 3.
Event rates and multivariate Cox proportional hazards models for baseline proneurotensin in relation to cause-specific mortality
| Age and sex adjusted | Fully adjusteda | |||||||
|---|---|---|---|---|---|---|---|---|
| All participants | Quartile 1-3 | Quartile 4 | P | All participants | Quartile 1-3 | Quartile 4 | P | |
| All-cause mortality | ||||||||
| No./events No. | 4632/1906 | 3474/1370 | 1158/536 | 4478/1823 | 3365/1316 | 1113/507 | ||
| HR (95% CI) | Ref 1.0 | 1.29 (1.17-1.43) | < .001 | 1.20 (1.08-1.33) | .001 | |||
| Cardiovascular diseases | ||||||||
| No./events No. | 4632/595 | 3474/419 | 1158/176 | 4478/562 | 3365/397 | 1113/165 | ||
| HR (95% CI) | 1.41 (1.18-1.68) | < .001 | 1.30 (1.08-1.56) | .005 | ||||
| Gastrointestinal diseases | ||||||||
| No./events No. | 4632/42 | 3474/24 | 1158/18 | 4478/42 | 3365/24 | 1113/18 | ||
| HR (95% CI) | 2.53 (1.37-4.67) | .003 | 2.37 (1.28-4.39) | .006 | ||||
| Mental and behavioral diseases | ||||||||
| No./events No. | 4632/90 | 3474/61 | 1158/29 | 4478/89 | 3365/61 | 1113/28 | ||
| HR (95% CI) | 1.62 (1.04-2.52) | .032 | 1.56 (0.99-2.34) | .057 | ||||
| Unspecific diseases | ||||||||
| No./events No. | 4632/64 | 3474/41 | 1158/23 | 4478/62 | 3365/40 | 1113/22 | ||
| HR (95% CI) | 1.91 (1.15-3.19) | .013 | 1.80 (1.07-3.04) | .028 | ||||
| Cancer | ||||||||
| No./events No. | 4632/683 | 3474/509 | 1158/174 | 4478/658 | 3365/493 | 1113/165 | ||
| HR (95% CI) | 1.10 (0.92-1.30) | .293 | ||||||
| Infectious diseases | ||||||||
| No./events No. | 4632/41 | 3474/30 | 1158/11 | 4478/35 | 3365/25 | 1113/10 | ||
| HR (95% CI) | 1.25 (0.62-2.50) | .531 | ||||||
| Endocrine diseases | ||||||||
| No./events No. | 4632/48 | 3474/34 | 1158/14 | 4478/45 | 3365/32 | 1113/13 | ||
| HR (95% CI) | 1.39 (0.75-2.59) | .300 | ||||||
| External causes | ||||||||
| No./events No. | 4632/58 | 3474/41 | 1158/17 | 4478/52 | 3365/39 | 1113/13 | ||
| HR (95% CI) | 1.35 (0.76-2.37) | .303 | ||||||
| Musculoskeletal diseases | ||||||||
| No./events No. | 4632/09 | 3474/6 | 1158/03 | 4478/09 | 3365/06 | 1113/03 | ||
| HR (95% CI) | 1.63 (0.41-6.56) | .487 | ||||||
| Urogenital diseases | ||||||||
| No./events No. | 4632/25 | 3474/20 | 1158/05 | 4478/24 | 3365/19 | 1113/05 | ||
| HR (95% CI) | 0.91 (0.34-2.43) | .854 | ||||||
| Respiratory diseases | ||||||||
| No./events No. | 4632/125 | 3474/92 | 1158/33 | 4478/122 | 3365/90 | 1113/32 | ||
| HR (95% CI) | 1.22 (0.82-1.1) | .331 | ||||||
| Neurological diseases | ||||||||
| No./events No. | 4632/107 | 3474/80 | 1158/27 | 4478/104 | 3365/77 | 1113/27 | ||
| HR (95% CI) | 1.11 (0.72-1.72) | .647 | ||||||
| Hematological diseases | ||||||||
| No./events No. | 4632/05 | 3474/04 | 1158/01 | 4478/05 | 3365/04 | 1113/01 | ||
| HR (95% CI) | 0.88 (0.99-7.88) | .91 | ||||||
Abbreviations: HR, hazard ratio; Pro-NT, proneurotensin; Ref, reference.
a Adjusted for age, sex, body mass index, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, diabetes, smoking, systolic blood pressure, and antihypertensive treatment.