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. 2022 Mar;29(3):71–76. doi: 10.1101/lm.053536.121

Figure 2.

Figure 2.

Age-dependent amelioration of spatial memory by PCAF activation (SPV106 at 25 mg/kg) in 3xTG mice. (A) At 3 mo of age, vehicle-treated 3xTG mice were delay-independently impaired on OL; treatment with SPV106 ameliorated this impairment. N = 12 Wt male, N = 12 Wt female, N = 12 3xTG male, N = 12 3xTG female. (B) At 6 mo of age, vehicle-treated 3xTG mice were delay-independently impaired on OL; treatment with SPV106 continued to ameliorate this impairment. N = 12 Wt male, N = 10 Wt female, N = 11 3xTG male, N = 11 3xTG female. (C) At 9 mo of age, vehicle-treated 3xTG mice were delay-independently impaired on OL, but treatment with SPV106 failed to attenuate this impairment. N = 12 Wt male, N = 10 Wt female, N = 11 3xTG male, N = 11 3xTG female. Data are mean ± SEM. (*) P < 0.05, (**) P < 0.01, (***) P < 0.001, indicates significant differences between sample and choice DR. (ΔΔΔ) P < 0.001 significantly different from vehicle-treated Wt mice, (θθθ) P < 0.001 significantly different from SPV106-treated Wt mice, (σσσ) P < 0.001 significantly different from SPV106-treated 3xTG mice.