Table 5.
Treatment-related toxicity of the included studies.
| Author and Year | Patients (n) | Hematological Toxicity n/N (%) | Nephrotoxicity n/N (%) | Xerostomia, n/N (%) | Other Manifestation |
|---|---|---|---|---|---|
| Any grade Grade ≥3 | Any grade Grade ≥3 | Any grade Grade ≥3 | |||
| Kratochwil et al. (12) | 40 | NR | NR | 19/40 (47.5) NR | NR |
| Sathekge et al. (13) | 73 | ① 27/73 (37) 5/73 (7) | 23/73 (32) 5/73 (7) | 62/73 (85) 0/73 (0) | Grade1/2 nause |
| ② 9/73 (12) 2/73 (3) | 15/73 (21) | ||||
| ③ 7/73 (10) 1/73 (1) | Anorexia 23/73 | ||||
| (32), | |||||
| Constipation | |||||
| 19/73 (26), | |||||
| Fatigue 37/73 (51), | |||||
| Weightloss 28/73 (38), | |||||
| Hypoalbuminemia | |||||
| 14/73 (19), | |||||
| Dysuria 13/73 (18), | |||||
| xerophthalmia 4/73 (6) | |||||
| Van der Doelen et al. (14) | 13 | ① 0/13 (0) / | 0/13 (0) / | 3/13 (100) 0/13 (0) | swallowing, speech, dysgeusia 13/13 (100) |
| ② 0/13 (0) / | |||||
| ③ 0/13 (0) / | |||||
| Satapathy et al. (15) | 11 | ① 8/11 (73) 1/11 (9) | 1/11 (9) 1/11 (9) | 8/11 (73) 1/11 (9) | Grade1/2 nausea 2/11 (18), |
| ② 5/11 (46) 0/11 (0) | Constipation 2/11 (18), | ||||
| ③ 5/11 (46) 2/11 (18) | Fatigue 3/11 (27), | ||||
| Weightloss 2/11 (18), | |||||
| Anorexia 3/11 (27) | |||||
| Feuerecker et al. (16) | 26 | ①15/26 (58) 9/26 (35) | 5/26 (19) 0/26(0) | 26/26 (100) 0/26(0) | Grade1 fatigue |
| ②13/26 (50) 7/26 (27) | 12/26 (36), | ||||
| ③14/26 (54) 5/26 (19) | Weightloss 3/26 (12), | ||||
| anorexia 8/26 (31) | |||||
| Sen et al. (17) | 38 | ①11/20 0/20 | NR | 37/38 (97) 5/38() | Weightloss 21/38 (55), |
| ②3/38 0/38 | Grade IV | ||||
| ③4/38 3/38 | Hearing loss 2/38 (), | ||||
| GradeI/2 nausea 9/38, |
① Anemia; ② leucopenia; ③ Thrombocytopenia; NR, not reported.