Table 1:
Baseline characteristics
| Fluid bolus (n=168) | No fluid bolus (n=169) | |
|---|---|---|
| Age, years | 61 (47–70) | 58 (46–68) |
|
| ||
| Sex | ||
| Female | 81 (48%) | 73 (43%) |
| Male | 87 (52%) | 96 (57%) |
|
| ||
| White | 115 (68%) | 121 (72%) |
|
| ||
| Acute physiology and chronic health evaluation II score | 21 (14–27) | 20 (16–27) |
|
| ||
| Body-mass index, kg/m2 | 27 (23–32) | 26 (22–32) |
|
| ||
| Active diagnoses since intensive care unit admission | ||
| Septic shock | 39 (23%) | 33 (20%) |
| Cardiogenic shock | 4 (2%) | 4 (2%) |
| Haemorrhagic shock | 4 (2%) | 4 (2%) |
| Pneumonia | 66 (39%) | 64 (38%) |
| Altered mental status | 69 (41%) | 72 (43%) |
| Gastrointestinal blood loss | 21 (12%) | 26 (15%) |
| Acute renal failure | 62 (37%) | 62 (37%) |
| Status epilepticus | 7 (4%) | 5 (3%) |
| Stroke | 10 (6%) | 10 (6%) |
| Acute coronary syndrome | 10 (6%) | 10 (6%) |
| Chronic obstructive pulmonary disease exacerbation | 7 (4%) | 4 (2%) |
|
| ||
| Indication for intubation | ||
| Hypoxic respiratory failure | 85 (51%) | 69 (41%) |
| Altered mental status | 47 (28%) | 52 (31%) |
| Facilitate another procedure | 16 (10%) | 25 (15%) |
| Hypercarbic respiratory failure | 16 (10%) | 15 (9%) |
| Impending airway collapse | 4 (2%) | 7 (4%) |
| Status epilepticus | 3 (2%) | 1 (1%) |
| Haemodynamic instability | 4 (2%) | 2 (1%) |
|
| ||
| Vasopressor receipt in 6 h before intubation | 28 (17%) | 28 (17%) |
|
| ||
| Baseline left ventricular ejection fraction (n=224) | 55% (55–60) | 55% (55–60) |
|
| ||
| Non-invasive ventilation receipt in 6 h before intubation | 44 (26%) | 37 (22%) |
|
| ||
| Lowest systolic blood pressure in 6 h before intubation, mm Hg | 103 (91–124) | 104 (89–125) |
Data given as median (IQR) or number (%) of patients.