Table 2:
Clinical outcomes for the fluid bolus vs no fluid bolus groups
| Fluid bolus (n=168) | No fluid bolus (n=169) | p value | Absolute difference (95% CI)* | Mean difference (95% CI)* | |
|---|---|---|---|---|---|
| Primary outcome | |||||
|
| |||||
| Cardiovascular collapse | 33 (20%) | 31 (18%) | 0·76 | 1·3% (−7·1 to 9·7) | NA |
|
| |||||
| Components of the primary outcome | |||||
|
| |||||
| Death within 1 h of intubation | 2 (1%) | 1 (1%) | 0·55 | 0·6%(−1·4 to 2·6) | NA |
| Cardiac arrest within 1 h of intubation | 7 (4%) | 2 (1%) | 0·8 | 3·0% (−0·5 to 6·4) | NA |
| New systolic blood pressure <65 mm Hg between induction and 2 min after intubation | 11 (7%) | 10 (6%) | 0·80 | 0·7% (−4·5 to 5·9) | NA |
| New or increased vasopressor between induction and 2 min after intubation | 32 (19%) | 31 (18%) | 0·86 | 0·7% (−76 to 9·0) | NA |
|
| |||||
| Exploratory periprocedural outcomes | |||||
|
| |||||
| Alternate composite outcome† | 39 (23%) | 42 (25%) | 0·72 | −1·6% (−10·8 to 7·5) | NA |
| New or worsening shock in 1 h after intubation | 53 (32%) | 47 (28%) | 0·45 | 3·8%(−6·0 to 13·6) | NA |
| New systolic blood pressure <90 mm Hg between induction and 2 min after intubation | 34 (20%) | 34 (20%) | 0·95 | 0·2% (−8·4 to 8·9) | NA |
| Lowest systolic blood pressure between induction and 2 min after intubation, mm Hg | 119 (95 to 140) | 119 (94 to 141) | 0·85 | NA | 1·1 (−6·4 to 8·5) |
| Change in systolic blood pressure from induction to 2 min after intubation, mm Hg | −9 (−26 to 0) | −6 (−26 to 0) | 0·93 | NA | −0·2 (−6·1 to 5·7) |
| Lowest arterial oxygen saturation between induction and 2 min after intubation, % | 94% (84 to 99) | 95% (82 to 99) | 0·95 | NA | −0·6 (−3·4 to 2·2) |
| Arterial oxygen saturation <90% | 56 (33%) | 58 (34%) | 0·78 | −1·4% (−117 to 8·8) | NA |
| Arterial oxygen saturation <80% | 28 (17%) | 33 (20%) | 0·46 | −3·1% (−11·5 to 5·2) | NA |
| Desaturation >3% between induction and 2 min after intubation | 72 (43%) | 72 (43%) | 0·96 | −0·3% (−10·9 to 10·4) | NA |
| Change in arterial oxygen saturation from induction to 2 min after intubation, % | −2% (−9 to 0) | −2% (−11 to 0) | 0·90 | NA | −0·9 (−3·5 to 17) |
|
| |||||
| Exploratory clinical outcomes | |||||
|
| |||||
| Ventilator-free days | 20 (0 to 25) | 19 (0 to 25) | 0·55 | NA | −0·7 (−3·7 to 1·7) |
| ICU-free days | 16 (0 to 24) | 14 (0 to 23) | 0·49 | NA | −0·6 (−2·9 to 1·6) |
| In-hospital mortality | 48 (29%) | 59 (35%) | 0·21 | −6·3% (−16·2 to 3·5) | NA |
Data given as median (IQR) or number (%) of patients. p value is based on the Mann-Whitney U test or χ2 test.
NA=not applicable.
*
Differences between categorical variables are displayed as absolute difference and differences between continuous variables are displayed as mean differences.
†
New systolic blood pressure <90 mm Hg, new or increased vasopressors, cardiac arrest within 1 h, death within 1 h. All exploratory outcomes we re pre-planned secondary outcomes specified in the statistical analysis plan.