. Author manuscript; available in PMC: 2022 Feb 17.

Published in final edited form as: Lancet Respir Med. 2019 Oct 1;7(12):1039–1047. doi: 10.1016/S2213-2600(19)30246-2

Table 3:

Safety outcomes

	Fluid bolus (n=168)	No fluid bolus (n=169)	p value	Mean difference (95% CI)
Lowest arterial oxygen saturation in 6–24 h after intubation, %	95% (92 to 97)	95% (92 to 97)	0·93	0·3 (−1·5 to 2·0)
Highest fraction of inspired oxygen in 6–24 h after intubation	0·5 (0·4 to 0·7)	0·5 (0·4 to 0·67)	0·73	−0·0 (−0·1 to 0·0)
Highest positive end–expiratory pressure in 6–24 h after intubation, cm H₂O	5 (5 to 8)	5 (5 to 8)	0·36	−0·3 (−0·9 to 0·4)
Cumulative diuretic dose in the 24 h after intubation, mg in furosemide equivalents	0 (0 to 60)	0 (0 to 0)	0·74	0·0 (−11·7 to 11·7)
Cumulative diuretic dose from intubation to 72 h after intubation, mg in furosemide equivalents	0 (0 to 60)	0 (0 to 57)	0·78	23·4 (−24·5 to 71·3)
Cumulative intravenous fluid administration from intubation to 72 h after intubation, mL	2061 (955 to 4411)	2036 (628 to 4317)	0·68	441 (−346 to 1229)

Data given as median (IQR) or number (%) of patients. p value is based on the Mann-Whitney U test or χ² test.