Figure 3. Effect of S1103Y variant on late sodium current (I_Na-L) in iPSC-CMs.

Representative traces of late sodium current (I_Na-L) in C1-SS (A) and C1-YY cells (B). I_Na-L is presented as the percentage of peak I_Na recorded at −30 mV. (C) Summary data of I_Na-L among C1-SS (n=10), C1-SY (n=12), and C1-YY (n=10) cells from three independent differentiation batches for each line. (D) APD₉₀ relative to baseline in each line before perfusion with the I_Na-L blocker GS967 (baseline), at 0.1 μM and 1 μM GS967 perfusion, and after wash-out. *p<0.05, **p<0.01, †p<0.001.