Table 2.

Dofetilide sensitivity by genotype in iPSC-CMs.

SCN5A genotype	SS		SY		YY
Cell line	C1-SS	A1-SS	C1-SY	A1-SY	C1-YY
[Dof]Δ100ms (nM) Median [IQR]	83.7 [11.9–1910]	1121 [29.4–2e+6]	3.5 [0.9–11.8]	4.1 [1.8–12.9]	4.2 [1.7–5.0]
ΔAPD90 at 10nM dofetilide Mean±S.E. (ms)	43.6±14.7	25.8±15.8	174.8±42.4	179.5±60.8	313.0±154.5
Afterdepolarizations, n/N (Lowest concentration producing afterdepolarizations)	1/8 (100 nM)	0/6	3/6 (10 nM)	2/5 (10 nM)	3/5 (10nM)