FIGURE 1.
Workflow employed for the identification of potential D-peptides targeting the 3CLpro active site. The number of D-tripeptides and D-tetrapeptides analyzed in parallel throughout the workflow is shown in parentheses, i.e., (number of D-tripeptides/number of D-tetrapeptides). The cut-offs used to select the peptides at every step are indicated as follows: cut-off for D-tripeptides/cut-off for D-tetrapeptides. These values were set on the basis of the results, so that a manageable number of D-peptides would be selected for the next step.