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Preliminary inhibition tests of 4P1-4 against 3CLpro. 4P1 and 4P2 inhibit the virus protease activity by more than 60%. 4P3 and 4P4 inhibit the virus protease activity more than 80%. Data shown are the mean ± STD from three independent measurements (n = 3). Asterisks mean that the data differs from the control (0 µM inhibitor) significantly at p < 0.01 (**) and p < 0.001 (***), level according to ANOVA and Tukey’s test.
