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. 2022 Feb 16;10(2):e004128. doi: 10.1136/jitc-2021-004128

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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CD19-targeted CAR T cells in a systemic WM in vivo model demonstrate initial efficacy followed by antigen escape mediated relapse. (A) Survival curve of SCID/beige mice after sublethal irradiation and engraftment of GFP/Luc+BCWM0.1 cells (day 0) and CAR +T cell treatment (day 7). Pooled data from two separate experiments. (B) Representative serial bioluminescent imaging over time. (C) hCD19 immunohistochemistry status of relapsed/residual tumor at time of humane endpoint. CAR, chimeric antigen receptor; WM, Waldenström macroglobulinemia.