Table 2 –
Univariate analyses of recipient and donor factors on OS, relapse, DFS and NRM
| Variable | Valid cases (n) | 5 year OS | 5 year relapse§ | 5 year DFS§ | 1 year NRM§ | ||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| % | P-value | % | P-value | % | P-value | % | P-value | ||
| Donor age, years | |||||||||
|
| |||||||||
| <30 | 39 | 42.2 | 0.67 | 24.2 | 0.12 | 42.9 | 0.37 | 28.6 | 0.36 |
| >30 | 80 | 37.2 | 39.2 | 32.6 | 20.2 | ||||
|
| |||||||||
| Recipient age, years | |||||||||
|
| |||||||||
| <40 | 85 | 42.6 | 0.049 | 34.3 | 0.79 | 38.4 | 0.083 | 19.2 | 0.097 |
| >40 | 34 | 28.5 | 35.3 | 29.1 | 32.4 | ||||
|
| |||||||||
| Donor sex | |||||||||
|
| |||||||||
| Female | 17 | 35.9 | 0.99 | 43.7 | 0.66 | 26.9 | 0.53 | 29.4 | 0.49 |
| Male | 102 | 38.8 | 33.1 | 37.3 | 21.9 | ||||
|
| |||||||||
| Recipient sex | |||||||||
|
| |||||||||
| Female | 46 | 39.0 | 0.97 | 37.9 | 0.47 | 32.5 | 0.59 | 19.8 | 0.51 |
| Male | 73 | 38.3 | 32.3 | 37.9 | 25.0 | ||||
|
| |||||||||
| Recipient-donor sex matching | |||||||||
|
| |||||||||
| Matched | 70 | 41.4 | 0.41 | 35.4 | 0.86 | 38.0 | 0.54 | 21.7 | 0.69 |
| Mismatched | 49 | 34.6 | 33.3 | 32.6 | 24.7 | ||||
|
| |||||||||
| Recipient-donor CMV matching | |||||||||
|
| |||||||||
| Matched | 91 | 40.8 | 0.17 | 32.8 | 0.33 | 38.2 | 0.14 | 21.1 | 0.52 |
| Mismatched | 26 | 29.4 | 43.5 | 25.4 | 26.9 | ||||
|
| |||||||||
| Transplant era | |||||||||
|
| |||||||||
| 1996-1999 | 15 | 60.0 | 0.45 | 28.6 | 0.049 | 50.0 | 0.60 | 21.4 | 0.11 |
| 2000-2003 | 44 | 34.1 | 50.0 | 31.8 | 13.6 | ||||
| 2004-2007 | 39 | 35.6 | 20.5 | 33.1 | 35.9 | ||||
| 2008-2011† | 21 | 38.6 | 31.2 | 40.7 | 19.9 | ||||
|
| |||||||||
| T cell deplete | |||||||||
|
| |||||||||
| Yes | 97 | 37.5 | 0.28 | 34.0 | 0.46 | 34.9 | 0.22 | 24.1 | 0.63 |
| No | 6 | 66.7 | 16.7 | 66.7 | 16.7 | ||||
|
| |||||||||
| Disease risk – EBMT score | |||||||||
|
| |||||||||
| Good | 51 | 36.7 | 0.89 | 26.7 | 0.12 | 31.2 | 0.72 | 28.0 | 0.30 |
| Intermediate/Poor | 67 | 39.3 | 40.8 | 38.1 | 19.6 | ||||
|
| |||||||||
| Stem cell source | |||||||||
|
| |||||||||
| BM | 54 | 46.0 | 0.13 | 37.7 | 0.59 | 39.5 | 0.49 | 18.9 | 0.41 |
| PBSC | 65 | 31.88 | 31.6 | 32.1 | 26.4 | ||||
|
| |||||||||
| Previous autografts | |||||||||
|
| |||||||||
| 0 | 112 | 40.1 | 0.028 | 34.0 | 0.62 | 37.2 | 0.063 | 21.7 | 0.18 |
| ≥1 | 7 | 14.3 | 42.9 | 14.3 | 42.9 | ||||
|
| |||||||||
| Donor KIR genotype | |||||||||
|
| |||||||||
| KIR AA | 35 | 48.9 | 0.060 | 38.7 | 0.60 | 46.5 | 0.087 | 8.7 | 0.019 |
| KIR BX | 84 | 34.4 | 32.8 | 31.3 | 28.9 | ||||
|
| |||||||||
| Donor Tel motif pattern | |||||||||
|
| |||||||||
| Tel-AA | 74 | 36.2 | 0.42 | 33.6 | 0.77 | 34.2 | 0.47 | 27.6 | 0.13 |
| Tel-BX | 45 | 42.3 | 36.1 | 38.2 | 15.6 | ||||
|
| |||||||||
| Donor Cen motif pattern | |||||||||
|
| |||||||||
| Cen-AA | 54 | 47.7 | 0.024 | 38.0 | 0.45 | 44.6 | 0.045 | 9.3 | 0.001 |
| Cen-BX | 65 | 31.2 | 31.5 | 28.6 | 34.4 | ||||
| Cen-AA | 54 | 47.7 | 0.010 | 38.0 | 0.75 | 44.6 | 0.031 | 9.3 | 0.005 |
| Cen-AB | 53 | 36.8 | 31.2 | 33.7 | 32.7 | ||||
| Cen-BB | 12 | 8.3 | 33.3 | 8.3 | 41.7 | ||||
§
NRM/DFS/Relapse data missing for one transplant.
†
Estimated incidence of OS, relapse and DFS at latest clinical follow-up (4 years) reported.
Statistically significant results (≤0.05) are italicized. OS = Overall survival, NRM = Non-relapse mortality, CMV = Cytomegalovirus, BM = bone marrow, PBSC = peripheral blood stem cells