Fig. 4.

Inhibition of microglia attenuated cognitive impairment. a Typical trajectories were presented on day 1 after SPS in control and SPS-exposed groups either treated with minocycline or vehicle intraperitoneally. b Spontaneous alternation was tested on day 1 after SPS in control and SPS-exposed groups either treated with minocycline or vehicle intraperitoneally (n = 9/group). c The number of Iba1-positive cell bodies was summarized (6 fields of 3 rats/group). d The representative Iba-1 (green) and DAPI (blue) stained images were captured in the CA1 and CA3 regions of the hippocampus. *P < 0.05, **P < 0.01, ***P < 0.001