Table 5.
Study information of scoping review TAND s according to study type
| Animal studies (n = 30) | Case studies (n = 47) | Cohort studies (n = 153) | |
|---|---|---|---|
| Sample characteristics |
Species: • Mice (n = 26; 87%) • Rats (n = 4; 13%) |
Sex: • Male (n = 25; 53%) • Female (n = 14; 30%) • Multiple case series (n = 8; 17%) Age distributiona: • Infant 0–3 years (n = 9; 19%) • Child 4–10 years (n = 18; 38%) • Adolescent 11–19 years (n = 16; 34%) • Adult 20–60 years (n = 17; 36%) • Older adult 60+ years (n = 1; 2%) |
Sex ratio reported: • 130 (85%) Age distributiona: • Infant 0–3 years (n = 90; 59%) • Child 4–10 years (n = 97; 63%) • Adolescent 11–19 years (n = 96; 63%) • Adult 20–60 years (n = 70; 46%) • Older adult 60+ years (n = 24; 16%) Sample size: • ≤ 50 (n = 88; 58%) • 51–100 (n = 28; 18%) • 101–200 (n = 17; 11%) • 201–500 (n = 13; 9%) • 501–1000 (n = 4; 3%) • ≥ 1001 (n = 3; 2%) Mixed caregiver patient cohort: • 7 (5%) |
| Clinical information |
Genetic information: • TSC1 (n = 8; 27%) • TSC2 (n = 22; 73%) |
Epilepsy information provided: • 39 (83%) IQ information provided: • 31 (66%) Genetic confirmation provided: • 11 (23%) |
Epilepsy information provided: • All (n = 110; 72%) • Some (n = 14; 9%) • None (n = 29; 19%) IQ information provided: • All (n = 93; 61%) • Some (n = 21; 14%) • None (n = 39; 26%) Genetic confirmation provided: • All (n = 26; 17%) • Some (n = 34; 22%) • None (n = 93; 61%) |
| World Bank Classification |
HIC (n = 30; 100%) LMIC (n = 0; 0%) Multisite HIC and LMIC N/A |
HIC (n = 33; 70%) LMIC (n = 14; 30%) Multisite HIC and LMIC N/A |
HIC (n = 138; 90%) LMIC (n = 10; 7%) Multisite HIC and LMIC (n = 5; 3%) |
| Sample identificationa | N/A | N/A |
Population (n = 9; 6%) Clinical (n = 108; 71%) Community (n = 47; 31%) |
| Quality rating |
Relatively high (n = 8; 27%) High (n = 22; 73%) |
Relatively high (n = 16; 34%) High (n = 31; 66%) |
Low (n = 4; 3%) Adequate (n = 26; 17%) Relatively high (n = 84; 55%) High (n = 39; 25%) |
aStudies could span multiple data extraction points (e.g. a study involving infants, children and adolescents); therefore, numbers and percentages reported within each category can exceed the maximum number of studies per study type. Percentages reported as percentage of study type total (animal studies: n = 30, case studies: n = 47, cohort studies: n = 153). N/A information not applicable to study type