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. 2022 Feb 11;126(12):1695–1703. doi: 10.1038/s41416-022-01717-6

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© The Author(s) 2022, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Progression-free survival: use of bevacizumab (BEV) with ixabepilone (IXA) significantly extended progression-free survival (5.5 vs 2.2 months, HR 0.33, 95% CI 0.19–0.55, p < 0.001) compared to IXA alone. b Overall Survival: overall survival was significantly longer in patients who received BEV in conjunction wiht IXA (10.0 vs 6.0 months, HR 0.52, 95% CI 0.31–0.87, p < 0.006). c Hazard ratios for progression-free survival versus treatment arm by subgroup: progression-free survival hazard radios were similar between arms among patients with prior BEV exposure (HR 0.36, 95% CI: 0.19–0.72, p = 0.003) and those who were BEV-naive (HR 0.27, 95%CI: 0.12–0.62, p = 0.002). Stratification by pre-treatment status, age, histology, and performance status are also shown. Error bars denote 95% confidence intervals (CI). d Hazard ratios for overall survival versus treatment arm by subgroup: similar hazard ratios for overall survival were observed between arms among patients with prior BEV exposure (HR 0.50, 95%: 0.25–1.02, p = 0.058) and those who were BEV-naive (HR 0.54, 95% CI: 0.24–1.22, p = 0.14). Stratification by pre-treatment status, age, histology, and performance status are also shown. Error bars denote 95% CI.