TABLE 1.
Drug | Time (h) | Species | Geometric mean (range) MIC, in mg/liter, determined by the following method:
|
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---|---|---|---|---|---|---|
NCCLSvis | NCCLSsp | XTTvis | XTTsp | |||
AMB | 24 | A. fumigatus | 0.68 (0.125–4) | 0.63 (0.5–2) | 0.63 (0.25–2) | 0.63 (0.5–2) |
A. flavus | 1.19 (0.5–4) | 1.20 (0.5–2) | 1.11 (0.5–2) | 1.15 (0.5–2) | ||
A. nidulans | 0.74 (0.25–4) | 0.72 (0.25–2) | 0.68 (0.25–2) | 0.66 (0.25–1) | ||
A. terreus | 1.11 (0.5–4) | 0.95 (0.5–4) | 1.07 (0.5–2) | 1.10 (0.5–2) | ||
A. ustus | 1.11 (0.5–2) | 0.88 (0.5–2) | 0.92 (0.5–4) | 1.12 (0.5–2) | ||
48 | A. fumigatus | 1.50 (1–4) | 1.26 (1–4) | 1.14 (0.5–4) | 1.15 (0.5–4) | |
A. flavus | 1.64 (1–4) | 1.38 (1–2) | 1.57 (1–4) | 1.45 (1–2) | ||
A. nidulans | 1.10 (0.25–4) | 0.87 (0.25–4) | 0.97 (0.25–4) | 0.95 (0.25–4) | ||
A. terreus | 2.89 (2–4) | 2.09 (2–4) | 2.64 (2–4) | 2.52 (2–4) | ||
A. ustus | 1.91 (1–4) | 1.36 (1–2) | 1.53 (1–4) | 1.47 (1–2) | ||
ITC | 24 | A. fumigatus | 2.39 (0.015–>32) | 1.15 (0.125–>32) | 1.36 (0.125–>32) | 1.38 (0.125–>32) |
A. flavus | 0.14 (0.063–0.25) | 0.10 (0.063–0.125) | 0.14 (0.0125–0.5) | 0.14 (0.063–0.25) | ||
A. nidulans | 0.13 (0.031–0.5) | 0.13 (0.063–0.25) | 0.13 (0.062–0.5) | 0.10 (0.062–0.5) | ||
A. terreus | 0.09 (0.031–0.25) | 0.09 (0.063–0.125) | 0.12 (0.062–0.5) | 0.11 (0.063–0.125) | ||
A. ustus | 0.40 (0.062–1) | 0.35 (0.063–1) | 0.54 (0.062–1) | 0.46 (0.063–1) | ||
48 | A. fumigatus | 2.89 (0.125–>32) | 2.41 (0.125–>32) | 2.96 (0.125–>32) | 2.10 (0.063–>32) | |
A. flavus | 0.19 (0.125–0.5) | 0.12 (0.063–0.25) | 0.26 (0.125–1) | 0.24 (0.125–0.5) | ||
A. nidulans | 0.16 (0.062–0.25) | 0.20 (0.063–2) | 0.17 (0.031–0.5) | 0.15 (0.031–0.5) | ||
A. terreus | 0.15 (0.062–0.5) | 0.14 (0.063–0.25) | 0.29 (0.062–0.5) | 0.23 (0.125–0.5) | ||
A. ustus | 1.48 (0.125–>32) | 0.89 (0.5–1) | 3.21 (0.125–>32) | 2.72 (0.25–>32) |