TABLE 3.
Overall relative (within 1 dilution) agreements and 95% CI limits between the visual and spectrophotometric readings and between the NCCLS and XTT methods
| Time (h) | Drug | Growth levela | % Agreement ± 95% CI for the following comparisons:
|
|||
|---|---|---|---|---|---|---|
| Visual vs spectrophotometric readings
|
NCCLS vs XTT methods
|
|||||
| NCCLSvis vs NCCLSspb | XTTvis vs XTTspb | NCCLSvis vs XTTvisb | NCCLSsp vs XTTspc | |||
| 24 | ITC | 0 | 51.4 ± 5.7d | 90.8 ± 3.3 | 88.0 ± 3.7 | 60.0 ± 11.1e |
| 1 | 92.8 ± 3.0 | 91.1 ± 3.3 | 92.7 ± 3.0 | 94.7 ± 5.1 | ||
| 2 | 87.7 ± 3.8 | 86.0 ± 4.0 | 86.8 ± 3.9 | 82.7 ± 8.6 | ||
| 3 | 67.8 ± 5.4e | 75.4 ± 4.9e | 79.8 ± 4.6e | 73.3 ± 10.0e | ||
| 4 | 68.1 ± 22.6d | 67.9 ± 5.3 | 68.3 ± 5.4 | 73.3 ± 10.0 | ||
| AMB | 0 | 96.7 ± 2.0 | 99.3 ± 0.9 | 96.7 ± 2.0 | 98.7 ± 2.5 | |
| 48 | ITC | 0 | 81.5 ± 4.4 | 95.3 ± 2.4 | 94.0 ± 2.7 | 84.0 ± 8.3 |
| 1 | 91.6 ± 3.1 | 90.9 ± 3.3 | 85.1 ± 4.1 | 77.3 ± 9.5 | ||
| 2 | 87.2 ± 3.8 | 83.2 ± 4.2 | 82.8 ± 4.3 | 73.3 ± 10.0 | ||
| 3 | 72.5 ± 5.1 | 69.5 ± 5.2 | 78.0 ± 4.7 | 54.7 ± 11.3 | ||
| 4 | 58.1 ± 5.6 | 67.5 ± 5.5d | 69.6 ± 5.2 | 48.0 ± 11.3 | ||
| AMB | 0 | 98.7 ± 1.3 | 100.0 ± 0.0 | 97.0 ± 1.9 | 98.7 ± 2.6 | |
a
See Table 2, footnote b.
b
A total of 300 comparisons.
c
A total of 75 comparisons.
d
The P value (obtained by a two-way ANOVA of log2 MIC end points derived by the two methods) was <0.01.
e
The P value was <0.05.