Table 3. ROC curve analysis assessing the various biomarkers among patients with bacteremic infection compared to those with no evidence of bacterial infection.
| Parameter | AUC | 95% CI | p-value for AUC | LR | Sensitivity | Specificity | Cut off value | NPV | PPV |
|---|---|---|---|---|---|---|---|---|---|
| (%) | (%) | (%) | (%) | ||||||
| nCD64: lCD64 | 0.86 | 0.75–0.98 | 0.0003 | 4.25 | 92.3 | 78.3 | > 7.4 | 70.6 | 94.7 |
| nCD64: mHLA-DR | 0.95 | 0.88–1.02 | < 0.0001 | 19.5 | 84.6 | 95.7 | > 0.34 | 90.9 | 88.0 |
| NE-WY | 0.78 | 0.63–0.93 | 0.005 | 3.54 | 61.5 | 82.6 | > 750.5 | 66.7 | 79.2 |
| NE-SFL | 0.84 | 0.70–0.98 | 0.0007 | 4.87 | 84.6 | 82.6 | > 49.75 | 73.3 | 90.5 |
| Automated IG% | 0.78 | 0.62–0.93 | 0.006 | 2.65 | 69.2 | 73.9 | > 0.85 | 60.0 | 81.0 |
| Abs auto IG | 0.74 | 0.57–0.91 | 0.017 | 3.98 | 69.2 | 82.6 | > 0.065 | 69.2 | 82.6 |
| CRP + | 1 | 1.00–1.00 | 0.0002 | >17 | 100 | 100 | > 12.5 | 100.00 | 95.0 |
| PCT * | 1 | 1.00–1.00 | 0.037 | >8 | 100 | 100 | >0.48 | 100.0 | 100.0 |
+ N = 24
*N = 10
AUC, area under the curve; CI, confidence interval; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; nCD64:lCD64, neutrophil CD64:lymphocyte CD64; nCD64:mHLA-DR, neutrophil CD64:monocyte HLA-DR; NE-WY, fluorescent light distribution width of the neutrophil area; NE-SFL, fluorescent light intensity of the neutrophil area; IG%, immature granulocyte percentage; CRP, C-reactive protein; Abs auto IG, absolute automated IG count.