Table 2. Responses to pulmonary rehabilitation of all patients completing pulmonary rehabilitation.
| Patients completing PR | Very good responder | Good responder | Moderate responder | Poor responder | |
|---|---|---|---|---|---|
| Patients, n (% patients completing PR) | 419 (100) | 108 (26) | 146 (35) | 123 (29) | 42 (10) |
| Δ 6MWD, m | 22.9 (67) | 86.7 (66.2) | 26.7 (31.9) # | -9 (46) #,¶ | -65.9 (52.7) #,¶,+ |
| · ≥ 30 m, % patients | 43.7 | 87.5 | 46.5# | 16 #,¶ | 0 #,¶,+ |
| · ≥ 60 m, % patients | 21.8 | 62.5 | 14.8 # | 1.7 #,¶ | 0 # |
| Δ CWRT, s | 206.4 (306) | 442.8 (325) | 237.7 (266.5) # | 61.9 (171.3) #,¶ | -96.1 (197.8) #,¶,+ |
| · ≥ 100 s, % patients | 51.9 | 82.5 | 60.6 # | 31.6 #,¶ | 0 #,¶,+ |
| · ≥ 200 s, % patients | 36.2 | 75.3 | 37.9 # | 12.3 #,¶ | 0 #,¶ |
| Δ COPM-P, points | 2.8 (1.8) | 4 (1.7) | 3.2 (1.6) # | 1.8 (1.3) #,¶ | 0.7 (1.3) #,¶,+ |
| · ≥ 2 points, % patients | 68.3 | 86.5 | 80.6 | 50.5 #,¶ | 22.9 #,¶,+ |
| · ≥ 4 points, % patients | 26.2 | 54.8 | 27.6 # | 5.5 #,¶ | 0 #,¶ |
| Δ COPM-S, points | 3.5 (2.2) | 4.7 (1.9) | 4 (1.8) # | 2.5 (1.9) #,¶ | 0.8 (1.5) #,¶,+ |
| · ≥ 2 points, % patients | 76.6 | 93.3 | 90.3 | 59.6 #,¶ | 26.5 #,¶,+ |
| · ≥ 4 points, % patients | 43.3 | 63.5 | 51.5 | 26.6 #,¶ | 2.9 #,¶,+ |
| Δ HADS-A, points | 1.7 (3.7) | 3.7 (3.7) | 2.2 (3.2) # | 0.2 (3.3) #,¶ | -0.9 (2.9) #,¶ |
| · ≥ 1.5 points, % patients | 50.5 | 71.9 | 54.9 # | 36.5 #,¶ | 19.4 #,¶ |
| · ≥ 3.0 points, % patients | 39.3 | 62.5 | 39.9 # | 27.1 # | 11.1 #,¶ |
| Δ HADS-D, points | 2.1 (3.7) | 3.9 (3.5) | 3 (3.5) | 0.5 (3.1) #,¶ | -0.7 (3) #,¶ |
| · ≥ 1.5 points, % patients | 53 | 69.8 | 62.4 | 37.4 #,¶ | 19.4 #,¶ |
| · ≥ 3.0 points, % patients | 38.7 | 57.3 | 47.4 | 23.4 #,¶ | 2.8 #,¶,+ |
| Δ mMRC dyspnea, grade | 0.3 (1.1) | 1 (1.1) | 0.3 (1) # | -0.1 (1) # | -0.2 (0.8) # |
| · ≥ 1 grade, % patients | 38.9 | 67.6 | 38.7 # | 23 # | 13.8 # |
| · ≥ 2 grades, % patients | 15.6 | 33.8 | 14 # | 6.9 # | 0 # |
| Δ SGRQ total score, points | 9.1 (14) | 19.2 (11.7) | 12.2 (12.7) # | 1.7 (10.5) #,¶ | -4.9 (9.3) #,¶,+ |
| · ≥ 4 points, % patients | 61.6 | 89.7 | 76.3 # | 36 #,¶ | 15.4 #,¶ |
| · ≥ 8 points, % patients | 50.9 | 83.5 | 63.7 # | 24.6 #,¶ | 2.6 #,¶,+ |
| Outcomes exceeding ≥ 1 MCID, % | 55.8 (27.8) | 82 (15.5) | 65 (16.1) # | 36.4 (18.7) #,¶ | 13.4 (15.1) #,¶,+ |
| Outcomes exceeding ≥ 2 MCID, % | 34.2 (25.9) | 62.7 (18.1) | 37.5 (18.1) # | 16.2 (14.1) #,¶ | 2.3 (6.1) #,¶,+ |
See legend Table 1 for explanation of abbrevations. Data are presented as mean (SD), unless otherwise stated. Δ, improvement (a minus sign means a deterioration); a lower score for HADS, mMRC dyspnea and SGRQ is an improvement. Outcomes exceeding ≥ x MCID, %: Percentage of outcomes which exceed the pre-defined minimal clinically important difference (MCID) at least x times.
#: p<0.01 versus very good responder cluster;
¶: p<0,01 versus good responder cluster;
+: p<0.01 versus moderate responder cluster.
When the value is significantly higher versus all the other clusters, the table-cell is colored red; if it is significantly lower, it is colored blue.