Figure.

The rate of mortality, clinical status over time, and the longitudinal course of the PaO₂/FiO₂ in invasively ventilated patients

(A) Kaplan Meier curve of the time to mortality. The hazard ratio and p value were calculated using Cox regression analysis and were adjusted for baseline imbalances (sex, diabetes, obesity [body-mass index >30 kg/m²], and cardiovascular disease; n=385). (B) Proportions of patients in each category over time according to an eight-point ordinal clinical scale (n=385). (C) The estimated longitudinal course of the ratio of PaO₂/FiO₂ during the first 14 days of invasive ventilation (n=56) calculated using a linear mixed model. Treatment, time, and time × treatment were entered as fixed effects, a random intercept on individual patient level was entered. The error bars indicate the SEs of the predicted values on each study day. FiO₂=fraction of inspired. PaO₂=partial pressure of oxygen. HR=hazard ratio. NIV=non-invasive ventilation. HFNO=high-flow nasal oxygen.