FIG 1.

Airway resistance is increased in CC16^−/− mice infected with Mp for the AIM and ELIM. Airway resistance during a methacholine challenge of WT (n = 9) and CC16^−/− (n = 16) male mice infected with Mp for the AIM and WT (n = 11) and CC16^−/− (n = 13) mice infected with Mp for the ELIM protocols. Non-infected saline controls are shown on each graph (dotted lines). Total airways respiratory resistance (Rrs) was calculated as a percentage over baseline in order to compare between separate experimental runs on the Flexivent machine. All mice were assessed for pulmonary function at 8 weeks of age. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001 by one-way ANOVA Sidak’s multiple comparison test.