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. Author manuscript; available in PMC: 2022 Dec 20.
Published in final edited form as: Chem Res Toxicol. 2021 Nov 24;34(12):2579–2591. doi: 10.1021/acs.chemrestox.1c00347

Figure 5.

Figure 5.

EET analogues 2 and 3 attenuate cisplatin (CDDP)-induced generation of reactive oxygen species (ROS) in LLC-PK1 proximal tubular cells. Pre-treatment with compound 2 (1 μM), 3 (1 μM), or 5 (1 μM) significantly decreased the augmented levels of (A) general cellular ROS and (B) mitochondria-specific superoxide anion in LLC-PK1 cells exposed to CDDP (20 μM) for 24 h, relative to vehicle control (One way analysis of variance, Holm-Sidak method, ***p < 0.001 vs. EtOH + CDDP group, α = 0.05).