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. Author manuscript; available in PMC: 2022 Dec 20.
Published in final edited form as: Chem Res Toxicol. 2021 Nov 24;34(12):2579–2591. doi: 10.1021/acs.chemrestox.1c00347

Figure 6.

Figure 6.

EET analogues 2 and 3 diminish cisplatin (CDDP)-induced MAPK signaling in LLC-PK1 proximal tubular cells. Pre-treatment with compound 2 (1 μM), 3 (1 μM), or 5 (1 μM) significantly reduced the higher ratio of phosphorylated variant to total variant for MAPKs (A) p38 and (B) JNK/SAPK in LLC-PK1 cells exposed to CDDP (20 μM) for 24 h, relative to vehicle control. Results are representative of three independent experiments (One way analysis of variance, Holm-Sidak method, *p < 0.05; ***p < 0.001 vs. EtOH + CDDP group, α = 0.05).