Figure 8.
The 14-3-3 PPI inhibitor promotes nuclear translocation of c-Abl. (A) Confocal microscopy images showing subcellular localisation of c-Abl in HeLa EGFP-Abl cells untreated or treated with 1 at 10 μM for 24 h. (B) Intensitometric analysis of confocal microscopy images of nuclear EGFP fluorescence on HeLa EGFP-Abl cells treated with increasing concentrations of 1 for 24 h; bars represent the mean ± SEM of the nuclear EGFP fluorescence intensity of seven representative fields; ****p < .0001.
