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Bcl-2 family members have an antiapoptotic function by blocking Bax/Bak directly in mitochondrial-mediated apoptosis. BCL-2 B-cell lymphoma 2, BH3 Bcl-2 homology 3, BAX BCL-2 associated X, BAK BCL-2 antagonist killer, MOMP mitochondrial outer membrane permeabilization. (Reprinted with permission from Ref. [104] © 2016 Nature Reviews Cancer)
