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. 2022 Feb 17;10:tkab045. doi: 10.1093/burnst/tkab045

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — The BCL-2 family proteins can be classified into three categories by BH domains, including the antiapoptotic Bcl-2 and the proapoptotic proteins Bax and Bik, which do not have the BH4 structural domain. Bcl-2 B-cell lymphoma-2, BH BCL-2 homology, Bcl-X_L B-cell lymphoma-extra large, Bcl-w BCL-2-like 2, Mcl-1 myeloid cell leukemia sequence 1, Bfl-1 BCL-2 related protein A1, Bax BCL-2-associated X protein, Bak BCL-2 antagonist/killer 1, Bad BCL-2-associated agonist of cell death, Bok Bcl-2-related ovarian killer, Bik BCL2-interacting killer, Bid BH3 interacting domain death agonist, Bim BCL-2-like 11, Hrk BCL-2 family members including harakiri, Blk B-lymphoid tyrosine kinase, Bnip3 BCL-2/adenovirus E1B 19KD interacting protein 3, Bnip3L BNIP3-like (Reprinted with permission from Ref. [109] © 2015 J Hematol Oncol)