Table 1.
Main epidemiological and virological features of cases identified with infection with the SARS-CoV-2 IHU variant
| Case no. | Age | Epidemiological features | Date of respiratory sample collection | Diagnostic qPCR Ct | Results of qPCR used to screen for the presence of SARS-CoV-2 spike mutations | Results of the TaqPath COVID-19 qPCR assay (Targets: ORF1, S, and N genes) | Genome GISAID Id. |
|---|---|---|---|---|---|---|---|
| 1 | 40s | Index case; travelled to Cameroon; family #1's case | 16/11/2021 | 27 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-pos.; P681H-pos. | Pos. for all three genes | EPI_ISL_7156955 |
| 2 | Child | Family #1's case | 22/11/2021 | 21 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-pos.; P681H-pos. | Pos. for all three genes | EPI_ISL_7314302 |
| 3 | Child | Family #2's case | 22/11/2021 | 15 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-pos.; P681H-pos. | Pos. for all three genes | EPI_ISL_7381031 |
| 4 | Child | Family #2's case | 22/11/2021 | 18 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-pos.; P681H-pos. | Pos. for all three genes | EPI_ISL_7381062 |
| 5 | 40s | Family #2's case | 24/11/2021 | 15 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-pos.; P681H-pos. | Pos. for all three genes | EPI_ISL_7156959 |
| 6 | 30s | Family #2's case | 24/11/2021 | 17 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-pos.; P681H-pos. | Pos. for all three genes | EPI_ISL_7314417 |
| 7 | Child | Family #2's case | 27/11/2021 | 19 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-pos.; P681H-pos. | Pos. for all three genes | EPI_ISL_7314514 |
| 8 | Child | - | 26/11/2021 | 26 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-pos.; P681H-pos. | Pos. for all three genes | EPI_ISL_7314471 |
| 9 | 40s | - | 25/11/2021 | 15 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-n.t..; P681H- n.t. | Pos. for all three genes | EPI_ISL_7552465 |
| 10 | 20s | - | 25/11/2021 | 16 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-n.t..; P681H- n.t. | Pos. for all three genes | EPI_ISL_7552470 |
| 11 | 40s | - | 01/12/2021 | 22 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-n.t..; P681H- n.t. | Pos. for all three genes | EPI_ISL_7552483 |
| 12 | 40s | - | 30/11/2021 | 15 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-n.t..; P681H- n.t. | Pos. for all three genes | EPI_ISL_7601710 |
| 13 | 40s | - | 01/12/2021 | 20 | L452R-neg.; E484K-pos.; E484Q-neg.; N501Y-n.t..; P681H- n.t | Pos. for all three genes | EPI_ISL_7552486 |
Ct, cycle threshold value; Id., identifier; neg., negative; N, nucleocapsid; no., number; N.t., not tested; ORF1, open reading frame 1; pos., positive; qPCR, real-time reverse transcription PCR; S, spike. All 13 respiratory samples were collected between mid-November 2021 and early December 2021.