Table 3.
Description of unpublished clinical trials on the effects of zinc and selenium against COVID-19.
| NCT Number | Interventions | Enrollment | Study Design | Location | Status |
|---|---|---|---|---|---|
| NCT04323228 | Dietary Supplement: Oral supplement enriched in antioxidants (15 μg selenium and 7.5 mg zinc once a day) Dietary Supplement: Cellulose-containing placebo capsules |
40 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Care Provider) Primary Purpose: Supportive Care |
Saudi Arabia | Recruiting |
| NCT04334512 | Drug: Hydroxychloroquine Drug: Azithromycin Dietary Supplement: Vitamin C Dietary Supplement: Vitamin D Dietary Supplement: Zinc (not specified) |
600 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment |
California, United States | Recruiting |
| NCT04335084 | Drug: Hydroxychloroquine Dietary Supplement: Vitamin C Dietary Supplement: Vitamin D Dietary Supplement: Zinc (not specified) |
600 | Allocation: Randomized Intervention Model: Single Group Assignment Masking: Double (Participant, Investigator) Primary Purpose: Prevention |
California, United States | Recruiting |
| NCT04435587 | Drug: Ivermectin pills/zinc sulfate (100 mg two times a day for three days) Drug: Combined ART/hydroxychloroquine/zinc sulfate (23 mg two times a day for five days) |
80 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment |
Thailand | Recruiting |
| NCT04446104 | Drug: Hydroxychloroquine sulfate tablets Drug: Ivermectin 3 mg tablets Drug: Zinc (80 mg once a day) Drug: Povidone-iodine Dietary Supplement: Vitamin C |
4257 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Prevention |
Singapore | Completed |
| NCT04468139 | Drug: Quercetin Dietary Supplement: Bromelain Drug: Zinc (50 mg once a day) Drug: Vitamin C |
60 | Allocation: N/A Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment |
Saudi Arabia | Recruiting |
| NCT04472585 | Drug: Ivermectin injectable solution Other: Injectable placebo Drug: Zinc (20 mg three times a day) Drug: Placebo empty capsule Drug: Oral ivermectin |
180 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
Pakistan | Recruiting |
| NCT04542993 | Dietary Supplement: Zinc picolinate (50 mg three times a day) Dietary Supplement: Resveratrol Dietary Supplement: Zinc picolinate placebo Dietary Supplement: Resveratrol placebo |
60 | Allocation: Randomized Intervention Model: Single Group Assignment Masking: Single (Participant) Primary Purpose: Supportive Care |
Washington, United States | Active, not recruiting |
| NCT04558424 | Dietary Supplement: Zinc gluconate (220 mg once a day) and ascorbic acid | 50 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Supportive Care |
Bangladesh | Not yet recruiting |
| NCT04621149 | Other: Chlorine dioxide Dietary Supplement: Zinc acetate (not specified) Drug: Famotidine Other: Placebo Dietary Supplement: Lactoferrin, green tea extract |
120 | Allocation: Randomized Intervention Model: Factorial Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
Arizona, United States | Recruiting |
| NCT04621461 | Dietary Supplement: Zinc sulfate (220 mg once a day) Drug: Placebo |
3 | Allocation: Randomized Intervention Model: Single Group Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment |
New York, United States | Completed |
| NCT04641195 | Dietary Supplement: Vitamin D3 (cholecalciferol) Dietary Supplement: Zinc gluconate (40 mg once a day) Dietary Supplement: Zinc gluconate (40 mg once a day) and vitamin D (cholecalciferol) Other: Placebo |
700 | Allocation: Randomized Intervention Model: Factorial Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
India | Recruiting |
| NCT04751669 | Dietary Supplement: Vitamin and trace elements (zinc 10 mg once a day and selenium 110 mg once a day) Dietary Supplement: Placebo |
300 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
Spain | Not yet recruiting |
| NCT04828538 | Dietary Supplement: Vitamin D Dietary Supplement: Omega DHA/EPA Dietary Supplement: Vitamin C, vitamin B complex and zinc acetate (100 mg once a day) |
3600 | Allocation: Randomized Intervention Model: Factorial Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Other |
Mexico | Active, not recruiting |
| NCT04869579 | Drug: Selenious acid (first day 2000 μg, following days 1000 μg) Other: Placebo |
100 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment |
Texas, United States | Not yet recruiting |
| NCT04935515 | Drug: Oral antibiotic, antihistamine, anti-inflammatory, multivitamins and zinc (not specified) Drug: Oral low dose steroid Drug: Intravenous antibiotics with low dose steroid Drug: Oral anti-coagulant |
25 | Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Supportive Care |
India | Completed |
| NCT04937556 | Dietary Supplement: Probiotic: Lactobacillus salivarius + vitamin D + zinc (not specified) Dietary Supplement: Placebo |
60 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment |
Spain | Recruiting |
| NCT05003492 | Combination Product: Combination therapy with zinc (15 mg twice daily) plus standard therapy Radiation: Photodynamic therapy Drug: Standard therapy |
2 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment |
Saudi Arabia | Not yet recruiting |
| NCT04377646 | Drug: Hydroxychloroquine Drug: Hydroxychloroquine (placebo) Drug: Zinc (15 mg once a day) Drug: Zinc (placebo) |
660 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Prevention |
Tunisia | Not yet recruiting |
| NCT04551339 | Dietary Supplement: PreserVision AREDS formulation soft gels or tablets (69.6 mg/day of zinc) Dietary Supplement: Multivitamin with 11 mg of zinc |
2700 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Other |
Minnesota, United States | Completed |
| NCT04584567 | Drug: Doxycyclin and placebo Drug: Doxycyclin and zinc (15 mg once a day) Drug: Placebo |
194 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Prevention |
Tunisia | Completed |
| NCT04780061 | Drug: Vitamin D3 50,000 IU Dietary Supplement: Vitamin C/zinc (8.3 mg three times a day) Dietary Supplement: Vitamin K2/D Other: Microcrystalline cellulose capsules Other: Medium chain triglyceride oil |
200 | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
Canada | Recruiting |