Table 3.
Characteristics of participants with dietary and genetic data
| Total (n = 602) |
Incident dementia (n = 125) | No incident dementia (n = 477) | p valuesa | |
|---|---|---|---|---|
| Mean (SD) n = cases/total caseb |
Mean (SD) n = cases/total caseb |
Mean (SD) n = cases/total caseb |
||
| Age at baseline examination |
70.6 (0.3) 602/602 |
70.6 (0.3) 125/125 |
70.6 (0.3) 477/477 |
0.49 |
| 5e-8 AD-PRS score |
− 0.004 (0.958) 602/602 |
0.013 (0.909) 125/125 |
− 0.008 (0.972) 477/477 |
0.83 |
| 1e-5 AD-PRS score |
− 0.034 (1.020) 602/602 |
− 0.012 (1.040) 125/125 |
− 0.039 (1.015) 477/477 |
0.79 |
| 1e-3 AD-PRS score |
− 0.042 (1.009) 602/602 |
− 0.061 (1.124) 125/125 |
− 0.036 (0.978) 477/477 |
0.81 |
| 1e-1 AD-PRS score |
− 0.0182 (1.008) 602/602 |
− 0.094 (1.027) 125/125 |
0.002 (1.003) 477/477 |
0.35 |
| Healthy dietary pattern (factor score 1) |
0.075 (1.253) 602/602 |
− 0.117 (1.315) 125/125 |
0.125 (1.233) 477/477 |
0.05 |
|
Western dietary pattern (factor score 2) |
− 0.039 (1.221) 602/602 |
− 0.050 (1.249) 125/125 |
− 0.036 (1.214) 477/477 |
0.91 |
| Energy intake kcal/day |
2182 (636) 602/602 |
2107 (579) 125/125 |
2202 (649) 477/477 |
0.14 |
| BMI |
26.8 (4.1) 597/602 |
26.1 (3.9) 124/125 |
27.0 (4.2) 473/477 |
0.03 |
| Serum cholesterol mmol/l |
5.9 (1.1) 599/602 |
6.0 (1.0) 125/125 |
5.9 (1.1) 474/477 |
0.45 |
| % n = cases/total caseb |
% n = cases/total caseb |
% n = cases/total caseb |
||
|---|---|---|---|---|
| APOE ε4 carriers |
29 175/602 |
40 50/125 |
26 125/477 |
0.003 |
| Sex (women) |
64 384/602 |
70 88/125 |
62 296/477 |
0.08 |
| Hypertensionc |
80 484/602 |
77 96/125 |
81 388/477 |
0.26 |
| Diabetes mellitus |
14 81/602 |
13 16/125 |
14 65/477 |
0.81 |
| Physical activity level | 0.93 | |||
| Sedentary/low |
10 59/592 |
11 13/124 |
10 46/468 |
|
| Low to moderate |
46 270/592 |
44 55/124 |
46 215/468 |
|
| Moderate to high |
44 263/592 |
45 56/124 |
44 207/468 |
|
| Educational level > compulsoryd |
40 238/597 |
40 50/124 |
40 188/473 |
0.91 |
| Current smoker |
16 95/595 |
13 16/124 |
17 79/471 |
0.30 |
ap values for comparisons between those that developed dementia and those that did not
bTotal number of cases are presented for all characteristics since there are missing data for some of the variables
cHypertension was defined as systolic blood pressure of ≥ 140 mmHg and/or a diastolic blood pressure of ≥ 90 mmHg
dMore than 6 years for birth cohort 1922 and more than 7 years for birth cohort 1930