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. 2022 Feb 15;21:15330338221077803. doi: 10.1177/15330338221077803

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Silencing SLC16A1-AS1 induces ferroptosis through downregulating SLC7A11. (A) The expression level of SLC7A11 in RCC cells and normal cells. (B) GSH/GSSG assay was conducted in RCC cells after silencing SLC16A1-AS1. (C) Liperfluo level was examined using immunofluorescence staining. (D) Western blot analyses of SLC7A11 and ferroptosis-related proteins (GPX4, COX2, and ACSL4) in RCC cells after silencing SLC16A1-AS1. *p<.05, **p<.01 compared with the NC group.

Abbreviations: GSH/GSSG, reduced glutathione and glutathione; RCC, renal cell carcinoma; GPX4, glutathione peroxidase 4; COX2, cyclooxygenase 2.