Fig. 7.

Overview of the changes induced by HSF diet (red arrows) and preventive effect of RB supplementation (green arrows). The HSF intake increases body weight and adiposity (obesity), leads to metabolic changes, cardiac dysfunction, increase of IL-6 and TNF-α levels in cardiac tissue and redox imbalance. The RB supplementation was able to prevent the metabolic changes, cardiac dysfunction, increase of cytokines and redox imbalance in cardiac tissue. HSF high-sugar fat diet, RB rice bran, IL-6 interleukin-6; TNF-α tumoral necrosis factor; SOD superoxide dismutase; CAT catalase and MDA malondialdehyde