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. 2021 Jul 18;71(3):579–588. doi: 10.1007/s00262-021-03018-y

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© The Author(s) 2021

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Fig. 3 — Changes in circulating Treg cells according to clinical outcomes. a In the responder group, the frequency of CD4⁺CD25⁺CD127^loFoxP3⁺ Treg cells decreased significantly 7 days after initiation of treatment compared with baseline (P = 0.034). b The frequency of CD4⁺CD25⁺CD127^loFoxP3⁺ Treg cells decreased significantly in patients with a PR (P = 0.035), and there was no significant change in patients with SD or PD. c In the responder group, the frequency of PD-1⁺CD4⁺CD25⁺CD127^loFoxP3⁺ Treg cells decreased significantly 7 days after initiation of treatment compared with baseline (P < 0.001). (D) In patients with a PR, the frequency of PD-1⁺CD4⁺CD25⁺CD127^loFoxP3⁺ Treg cells decreased significantly (P < 0.001), and a significant decline was also observed in patients who showed a durable response (P = 0.002)