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. 2022 Feb 4;13:808101. doi: 10.3389/fimmu.2022.808101

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Copyright © 2022 Zhang, Lu, He, Xu, Xiang, Nie, Lin, Chen, Zhou, Yin, Xie, Zhang, Zheng, Zhu, Cai, Li, Chao and Cai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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X-tile plots of the prognostic marker CRP levels on HCC patients treated with PD-1 inhibitors. X-tile plot showed the χ2 log-rank values created when the cohort was divided into two populations. The cut-point highlighted by the black/white circle (A) was demonstrated on a histogram of the entire cohort (B) and a Kaplan–Meier plot (C). CRP levels were divided at the optimal cut-point, as defined by the most significant point on the plot (≤ 20.9 mg/L and > 20.9 mg/L of HCC patients treated with PD-1 inhibitors, P < 0.01).