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. 2022 Feb 4;12:735736. doi: 10.3389/fendo.2021.735736

Table 3.

Multiple regression analysis of different VD3 levels.

Outcomes Model 1 Model 2 Model 3 Model 4 p for interaction
OR (95% CI) p-Value OR (95% CI) p-Value OR (95% CI) p-Value OR (95% CI) p-Value
IR group <0.001
N1 (<30) 2.33 (1.83~2.96) <0.001 2.63 (2.02~3.43) <0.001 2.02 (1.55~2.64) <0.001 2.11 (1.57~2.83) <0.001
N2 (30–50) 2.01 (1.73~2.34) <0.001 2.23 (1.89~2.63) <0.001 1.52 (1.31~1.78) <0.001 1.52 (1.29~1.78) <0.001
N3 (50–80) 1.87 (1.68~2.07) <0.001 1.88 (1.69~2.09) <0.001 1.31 (1.18~1.44) <0.001 1.28 (1.16~1.41) <0.001
N4 (>80) 3.27 (2.69~3.98) <0.001 3.22 (2.63~3.94) <0.001 2.23 (1.81~2.74) <0.001 2.16 (1.75~2.67) <0.001
IGT group <0.001
N1 (<30) 1.54 (1.33~1.8) <0.001 1.63 (1.36~1.94) <0.001 1.46 (1.21~1.75) <0.001 1.41 (1.17~1.70) <0.001
N2 (30–50) 1.31 (1.19~1.43) <0.001 1.29 (1.17~1.43) <0.001 1.18 (1.08~1.3) <0.001 1.18 (1.07~1.29) 0.001
N3 (50–80) 1.18 (1.11~1.26) <0.001 1.19 (1.1~1.27) <0.001 1.08 (1.01~1.15) 0.016 1.09 (1.02~1.16) 0.007
N4 (>80) 1.6 (1.39~1.84) <0.001 1.59 (1.37~1.85) <0.001 1.28 (1.1~1.48) 0.001 1.22 (1.05~1.42) 0.009
DM group <0.001
N1 (<30) 1.43 (1.24~1.65) <0.001 1.51 (1.27~1.78) <0.001 1.37 (1.15~1.62) <0.001 1.31 (1.1~1.55) 0.002
N2 (30–50) 1.29 (1.18~1.41) <0.001 1.31 (1.19~1.44) <0.001 1.2 (1.09~1.32) <0.001 1.19 (1.08~1.31) <0.001
N3 (50–80) 1.18 (1.1~1.26) <0.001 1.22 (1.13~1.32) <0.001 1.11 (1.04~1.2) 0.002 1.13 (1.06~1.20) <0.001
N4 (>80) 1.51 (1.32~1.73) <0.001 1.53 (1.31~1.78) <0.001 1.27 (1.09~1.47) 0.002 1.22 (1.05~1.42) 0.01

Model 1: non-adjusted. Model 2: adjusted for gender, age, and race. Model 3: Model 2 + adjusted for ALT, AST, TG, TC, GGT, ALB, and HDL. Model 4: Model 3 + adjusted for smoking, alcohol use, income, and education.

VD3, vitamin D3; IR, insulin resistance; IGT, impaired glucose tolerance; DM, diabetes mellitus; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TG, triglycerides; TC, total cholesterol; GGT, γ-glutamyl transpeptidase; ALB, albumin; HDL, high-density lipoprotein.