Fig. 2.

SCDEs inhibit apoptosis of injured neurons via autophagy in vivo. A These cells were stained with TUNEL in vivo. Scale bar, 100 μm. B Quantification of the number of apoptotic cells in different groups. C Western blotting results indicated that the SCDE-treatment group expressed higher protein levels of autophagic markers in vivo compared with those of other groups. D–F Quantification of LC3-1/2, Beclin-1 and P62 expression levels Data are presented as the mean ± SEM, two-way ANOVA with Tukey’s post-hoc test, n = 4. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Chlo chloroquine, SCDEs Schwann cell-derived exosomes