Fig. 4.

SCDEs inhibit the Akt/mTOR signaling pathway by downregulating EGFR. A Western blotting indicated that when H₂O₂-induced injury occurred, EGFR was downregulated after SCDE treatment. B Semi-quantification of EGFR expression. C, D The phosphorylation levels of p-Akt and p-mTOR were both notably decreased by SCDE treatment following H₂O₂-induced injury. E, F Semi-quantification of p-Akt, Akt, p-mTOR and mTOR expression. Data are presented as the mean ± SEM, two-way ANOVA with Tukey’s post-hoc test, n = 4. **P < 0.01. SCDEs Schwann cell-derived exosomes, p- phosphorylated