Figure 1: Knowledge of biology has been fueled by technology development, which has resulted in new diagnostics and therapeutics benefiting human health.
Microscopy enabled discovery of cellular structures, revealed bacteria as infection-causing agents, and spurred the development of antibiotics. Immunoassays have been used to discover distinct proteins such as enzymes allowing development of drugs targeting of specific proteins and creation of diagnostics such as viral antigen tests. DNA and RNA sequencing devices have enabled diagnostic differentiation of infectious agents such as viruses and have driven development of targeted gene therapies. Flow and mass cytometry allow characterization and quantification of multiple populations of cells and are used for diagnosis of blood-based cancers and in the development of antibody-based therapies. Finally, multiplexed imaging reveals novel spatial relationships fueling the next wave of diagnostics and therapies.