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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Trends Neurosci. 2022 Jan 13;45(3):184–199. doi: 10.1016/j.tins.2021.12.004

Figure 1: Genes implicated in lysosomal function and lysosomal processes are at the crossroads of several neurodegenerative diseases.

Figure 1:

Risk variants in lysosomal genes have been identified in several neurodegenerative diseases, including AD, PD, ALS and FTD. The implicated genes are involved in a broad range of lysosome-related pathways, such as acidification, endocytosis, autophagy, mitophagy and ER-golgi-lysosome trafficking. The risk variants may mediate their pathogenicity in/through various cell types, including neurons, microglia and astrocytes. Epigenetic pathways and systemic factors likely modulate the risk of these variants for the disease and thus contribute to the heterogeneity in disease progression.