Freedom from GI Bleeding, Device Malfunction, Stroke, and MCS Infection by Era. Freedom from adverse events as compared across eras (2011–2015 vs. 2016–2020): (A) GI bleeding, (B) Device Malfunction / Pump Thrombosis, (C) Stroke, (D) MCS Infection. GI, gastrointestinal; MCS, mechanical circulatory support. Shaded areas indicate 70% confidence limits, p (log-rank) = <0.0001, Event: Death (censored at transplant or cessation of support).