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. Author manuscript; available in PMC: 2023 Feb 16.
Published in final edited form as: Soft Matter. 2022 Feb 16;18(7):1342–1349. doi: 10.1039/d1sm01557e

Figure 5. The interplay between entropy-driven complexation and enthalpy-driven phase separation may underlie the closed-loop phase behavior of RNA-polycation mixtures.

Figure 5.

A scheme summarizing the proposed mechanism for the closed-loop phase diagram exhibited by RNA-polycation mixtures. Panels (a-f) are the complexation and phase separation behavior of the system with increasing temperatures. RNA is drawn as red chains, counter-ions are drawn as blue circles, and polycations are drawn as green circles.