Table 1.

Gene list of extracellular matrices downregulated after neoadjuvant therapy (NAT) in PDAC tissue.

Gene symbol	Gene name (Downregulated by NAT)	Fold Change
LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	0.002
PCSK6	proprotein convertase subtilisin/kexin type 6	0.006
LAMB3	laminin, beta 3	0.007
ANXA2	annexin A2	0.011
LAMC2	laminin, gamma 2	0.012
EFNA5*	ephrin-A5*	0.013
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.013
ITGA6	integrin, alpha 6	0.021
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.021
CD151	CD151 molecule (Raph blood group)	0.025
LAMA3	laminin, alpha 3	0.025
PKM	pyruvate kinase, muscle	0.028
PLOD3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.031
SLPI	secretory leucocyte peptidase inhibitor	0.031
PLAT	plasminogen activator, tissue	0.032
LGALS3	lectin, galactoside-binding, soluble, 3	0.038
CST3	cystatin C	0.044
MMP28	matrix metallopeptidase 28	0.047
COL7A1	collagen, type VII, alpha 1	0.047
LOXL2	lysyl oxidase-like 2	0.048
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.051
IBSP	integrin-binding sialoprotein	0.053
ACHE	acetylcholinesterase (Yt blood group)	0.054
COL17A1	collagen, type XVII, alpha 1	0.064
NDNF	neuron-derived neurotrophic factor	0.070
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.073
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.089
TINAG	tubulointerstitial nephritis antigen	0.093
BMP7	bone morphogenetic protein 7	0.099
AGRIN	agrin	0.102
MUC4	mucin 4, cell surface associated	0.175
DMBT1	deleted in malignant brain tumours 1	0.176

EFNA5 is nominated as a candidate (*).